January 2019
Dr Lynn Quek, MRC MHU, Weatherall Institute of Molecular Medicine
Single cell transcriptomic and proteomic analysis of granulocyte-monocyte and erythroid differentiation in normal haematopoietic progenitors and in Acute Myeloid Leukaemia.
Dr Gillian Farnie, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences
Investigating tumour heterogeneity to discover mechanisms of inherent and therapy induced resistance
Prof. Anne Kiltie, CRUK/MRC Oxford Institute of Radiation Oncology
Development of a human gastrointestinal epithelial organoid assay to identify non-toxic chemoradiation combinations for abdominal and pelvic tumours
Dr Shivan Sivakumar, Department of Oncology
Mapping the T cell architecture of pancreatic cancer
Dr Natalia Gromak, Sir William Dunn School of Pathology
Molecular Mechanism of APOBEC3B-Dependent targeting of pathological R loops in breast cancer
Dr Benjamin Schuester-Bockler, Nuffield Department of Medicine, Big Data Institute
Determining the mechanism of mutagenesis in gastric and oesophageal adenocarcinomas
Dr Jacqueline Boultwood, Nuffield Division of Clinical Laboratory Sciences
Single-cell analysis of haematopoietic stem cells in advanced myelodysplastic syndromes: identification of new therapeutic treatments/targets
Dr Jordan Becker, Wellcome Centre for Human Genetics
Dissecting the mechanism of BRCA1-BARD1 complex function in DNA double-strand break repair
Dr Jan Bornschein, Translational Gastroenterology Unit
Transcriptome profiling of different stages of inflammatory, preneoplastic, and neoplastic alterations of the gastric mucosa by RNA-sequencing. Analysis of risk-factor associated gene expression signatures and virtual microdissection to enable analysis of epithelial-stromal interaction.
Dr Fumiko Esahi, Sir William Dunn School of Pathology
Exploring the role of BRCA1 AND PALB2 in myeloid differentiation
Prof Sarah Blagden, Department of Oncology
The Role of Olaparib and PARPs in the Cellular Stress Response
Dr Jakub Kopycinski, Nuffield Department of Medicine
Use of High-Definition immune profiling to understand mechanisms underpinning control of high-risk Human Papillomavirus (hrHPV) in exposed women.
Dr Dawn O’Reilly, Department of Oncology
Examine the feasibility of long-range sequencers to build a comprehensive transcriptome isoform blueprint of human breast cancer cells– “a proof of concept” study.
Dr Michael Tellier, Sir William Dunn School of Pathology
Understanding the function of the cyclin-dependent kinase 10 (CDK10) and cyclin M (CycM) in cancer and STAR syndrome, a developmental genetic disease
Prof Ahmed Ahmed, Nuffield Department of Women’s & Reproductive Health
Molecular validation of a putative novel aggressive molecular subtype of ovarian cancer