June 2020

Ms Marketa Tomkova & Mr Michael McClellan Ludwig Cancer Research

Detection of non-clonal mutations and mutational signatures by single-molecule sequencing

Ms Yurena Vivas-García Ludwig Institute for Cancer Research, Nuffield Department of Medicine

Identification of pathways driving resistance to drugs targeting fatty acid saturation in cancer

Prof Simon Leedham & Ms Nadia Nasreddin Nuffield Department of Medicine

The WNT signalling pathway landscape of colitis-associated colorectal cancer

Ms Mara Artibani Nuffield Department of Women’s and Reproductive Health / Weatherall Institute of Molecular Medicine

Establishing a 3D model of minimal residual disease for drug screening

Prof Matthew Freeman Sir Dunn School of Pathology

Developing animal models of iRhom2, a potential new target in KRAS-induced cancer

Dr Lonnie Swift Department of Oncology

Exploiting synthetic defects in metabolism and DNA repair to improve the treatment of glioma

Prof Geoff Higgins Department of Oncology

Preclinical evaluation of Atovaquone as an immune therapy sensitiser

Prof Richard Gibbons Radcliffe Department of Medicine /Nuffield Division of Clinical Laboratory Sciences /WIMM Weatherall Institute of Molecular Medicine

Genome-wide optical mapping of replication stalling

Ms Ysobel Baker & Prof Tom Brown Department of Chemistry

New chemical architectures for the therapeutic targeting of RNA

Dr Benjamin Fairfax Department of Oncology

Characterising the cfDNA methylome in patients with metastatic melanoma treated with immune checkpoint blockade